Modulating Cytotoxic Effector Functions by Fc Engineering to Improve Cancer Therapy
نویسندگان
چکیده
منابع مشابه
Modulating Cytotoxic Effector Functions by Fc Engineering to Improve Cancer Therapy.
In the last two decades, monoclonal antibodies have revolutionized the therapy of cancer patients. Although antibody therapy has continuously been improved, still a significant number of patients do not benefit from antibody therapy. Therefore, rational optimization of the antibody molecule by Fc engineering represents a major area of translational research to further improve this potent therap...
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IgG antibodies contain a conserved N-glycosylation site on the Fc domain to which a complex, biantennary glycan is attached. The fine structures of this glycan modulate antibody effector functions by affecting the binding affinity of the Fc to diverse Fc receptor family members. For example, core fucosylation significantly decreases antibody-dependent cellular cytotoxicity (ADCC), whereas termi...
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Agonistic antibodies directed against immunostimulatory receptors belonging to the tumor necrosis factor receptor (TNFR) superfamily are emerging as promising cancer immunotherapies. Several Fc engineering approaches discovered recently can augment the anti-tumor activities of TNFR antibodies by enhancing their agonistic activities and/or effector functions. In this study, we compared these app...
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ژورنال
عنوان ژورنال: Transfusion Medicine and Hemotherapy
سال: 2017
ISSN: 1660-3796,1660-3818
DOI: 10.1159/000479980